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The Wrinkle Defence Gel formulation contains a high percentage of Oxygen Ozone with Macadamia Oil, which provides the skin with a high antioxidant benefit to protect the skin against the signs of ageing.

The Hyaluronic Acid deeply moisturises the skin by bringing water to the tissues, while the Macadamia Oil acts in synergy to soothe and regenerate the skin. The fast absorption formulation is designed for all skin types, especially oily skin, and gives a feeling of immediate freshness. The skin is firm, luminous, and regenerated.

Results from our Antera 3D Skin analysis regularly show up to a 50% reduction in pore size after one week of daily use.


✓ Reduces Pore Size
✓ Help Smoothen Skin Texture
✓ Stimulates Collagen & New Elastic Fibres
✓ Encourages Regular Cellular Renewal
✓ Fast Absorption & Fast Acting
✓ Recovers Skin from Oxidative Stress


Oxygen Ozone repairs the skin cells from damage caused by free radicals and oxidative stress. The result is a hydrated and active cell, which leads to younger and firmer skin within weeks.

✓ Enhancement of Tissue Oxygenation
✓ Improved Skin Firmness & Elasticity
✓ Oxidative Stress Protection
✓ Cellular Vitality Improvement
✓ Skin Rejuvenation


Key Active Ingredients
Oxygen Ozone | Hyaluronic Acid | Macadamia Oil

Ingredient Listing
Aqua | Oxygen | Carbomer | Triethanolamine | Macadamia Ternifolia Seed Oil | Glycerin | Propylene Glycol | Imidazolidinyl Urea | Potassium Sorbate | Disodium Edta | Lecithin | Pentylene Glycol | Hyaluronic Acid


As time goes by due to normal ageing, the metabolism of the skin cell slows down as it decreases its ability to transform oxygen and retain water.

The unique combination of Oxygen Ozone, the core active ingredient in the entire L'Ossigeno range, offers a re-oxygenating effect on the skin cells to favour skin cell renewal, resulting in a more elastic and younger final appearance of the skin. The cellular metabolic reactivation enhances the production of new collagen and new elastic fibres, restoring the skins natural radiance.

The chemical structure of the Oxygen Ozone combination allows a rapid absorption through the skin layers, engendering an immediate and effective result. The combination has been scientifically tested and proven to increase cellular vitality at both the University of Pisa and the University of Genova.

The unique combination of Oxygen Ozone is a patented process created by Dr. Roberto Albertelli.


Splash face with warm water and wash with a cleanser, preferably the Deep Regenerating Cleanser (no need to tone when using this). The activated Oxygen Ozone & Hyaluronic Acid will cleanse and make the skin highly receptive to further treatment.

Apply a small amount of the Hyaluronic Serum Concentrate onto the fingertips and massage gently onto the face with circular movements until completely absorbed. Focus on areas under the eyes, in the T section, and areas of dryness. For best results, apply in the morning and in the evening.

Apply a small amount of the Wrinkle Defence Treatment onto the fingertips and massage gently onto the face with circular movements until completely absorbed. For best results, apply in the morning and in the evening after facial cleansing.

If needed for dryer skin, apply a L'Ossigeno moisturising cream-based product for extra hydration and anti-ageing benefits.


The Wrinkle Defence Treatment is powerful gel treatment that reduces the size of the pores, while healing and protecting the skin. It has a rapid absorption and gives significant pore size reduction in less than a week of daily use.

- Dr. Roberto Albertelli


University of Genoa

Genova, Italy

The L'Ossigeno Gel Treatments are able to protect the epidermis from factors that cause oxidative stress such as ageing and pollution.
University of Pisa

Department of Microbiology
The Oxygen Ozone present in the L'Ossigeno Skincare Collection increase cellular activity in skin cells by 300%.

BIOXID-AD Laboratory

Tuscany, Italy

L'Ossigeno products work effectively on skin restoring the cellular metabolic balance. Consequently, the cell is able not only to physiologically react to endogenous and exogenous damages but also to absorb in a faster way the active ingredients present in the product.


BioBasic Laboratory

Milan, Italy

Oxygen Ozone is capable of reducing interleukin production in human keratinocyte cells in vitro.

BioBasic Laboratory

Milan, Italy

The anti-ageing L'Ossigeno collection offers a repairing action against environmental stress (pollution and UV radiation) tested on the in vitro keratinocytes cells.

Can I use this if I'm pregnant or breastfeeding?
Yes, oxygen ozone is completely safe. All products in our collection that do not contain Vitamin A are safe to use while pregnant or breastfeeding. Products that contain Vitamin A are recommended to speak with a doctor before using. 

What if I do not like the products?
If you are not 100% satisfied with your L'Ossigeno skincare at any stage within 30 days, email us and you will receive a 100% refund, even if the products are used.

Where are the products made?
The L'Ossigeno collection is made in Forte Dei Marmi, in Tuscany, Italy. Our main office is in Adelaide, Australia where products are dispatched from.

How long is shipping?
Complimentary express shipping within Australia: 1-2 Business Days.
DHL Express worldwide: 4-5 Business Days. 

How long will one product last me?
On average, our 50ml products last for about 2 months of daily use. 

What is Oxygen Ozone and how does it help the skin?
Oxygen Ozone the core ingredient in the entire L'Ossigeno collection, which is an ionised Oxygen gel that directly and instantly provides the skin cells with oxygen ions. By providing oxygen directly to the skin cells, the cell is nourished, the vitality of the cell increases, and the skin is protected from oxidative stress and free radicals. This process gives the skin a younger & firmer appearance. Oxygen Ozone also makes the skin more receptive to the additional active ingredients present in the products.

Are there preservatives in L'Ossigeno?
L'Ossigeno has less preservatives than most other skincare products on the market due to the natural anti-bacterial nature of Oxygen Ozone. L'Ossigeno has no parabens and uses no fragrances.

Are L'Ossigeno products Vegan?
Yes, all products in the L'Ossigeno collection that do not have collagen as an ingredient are vegan. 

What does L'Ossigeno mean?
L'Ossigeno is Italian for "the Oxygen" as our entire collection is made using our patented core ingredient Oxygen Ozone.

Customer Reviews

Based on 12 reviews
janne bourne
my opinion on products

I have been using all the products for a few months now and I have really noticed an improvement in my skin. I would recommend the range to anyone and everyone. Can't recommend it enough.

Thank you so much Janne!!

Dispenser doesn't work

Cannot access product seamlessly as dispenser clogs up immediately & need to take top off & to get product out (wrinkle defence).
Poor design and quality control by company on behalf of consumer, disappointed.

Hi Susie,

Sorry I have just seen your review now. Extremely sorry about your pump, we will send you out a replacement immediately!

Best regards,

Lynne Harvey
Skin care.

I have always tried to look after my skin and frequently try new products. I have found this skin care range to be easy to use and beautiful results are occurring. My skin is softer and more radiant . I would recommend this range to everyone to try.

Thank you Lynne, we are so happy to hear that you are enjoying our collection!

Marta Frizzo
I believe in you!

Wrinkle Defence Treatment is the secret of my makeup base, in one product I find the solution for all combination/dry skin.

Anti-ageing capabilities tested & proven at

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